In Fever 1793 by Laurie Halse Anderson, the main character Mattie (a.k.a Matilda) faces and experiences the fever epidemic of 1793. Her friend Polly dies, and soon her mother is sick in bed and she is forced to flee to the country with her grandfather but on the way grandfather gets sick and they are thrown out of the wagon. Mattie is then forced to take care of her grandfather and survive in the wilderness now....
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