The tale begins with Jonathan Harker, a newly qualified English solicitor, journeying by train and carriage from England to Count Dracula's crumbling, remote castle. At first enticed by Dracula's gracious manner, Harker soon discovers that he has become a prisoner in the castle. He also begins to see disquieting facets of Dracula's nocturnal life. One night while searching for a way out of the castle, and against Dracula's strict admonition not to venture outside his room at night, Harker falls under the spell of three wanton female vampires, the Brides of Dracula. He is saved at the last second by the Count, however, who ostensibly wants to keep Harker alive just long enough to obtain needed legal advice and teachings about England and London (Dracula's planned travel destination was to be among the "teeming millions"). Harker barely escapes from the castle with his life. Soon Dracula is menacing Harker's devoted fiancée, Wilhelmina "Mina" Murray, and her vivacious friend, Lucy Westenra. Lucy begins to waste away suspiciously and later she and her mother are attacked by a wolf. Mrs Westenra, who has a heart condition, dies of fright, and Lucy apparently dies soon after. Lucy is buried, but soon afterward the newspapers report children being stalked in the night by beautiful lady. Realising Lucy is a vampire, she is tracked down by VanHelsing & co and staked. Around the same time, Jonathan Harker arrives home from recuperation in Budapest (where Mina joined and married him after his escape from the castle); he and Mina also join the coalition, who turn their attentions to dealing with Dracula.
After Dracula learns of Van Helsing and the others' plot against him, he takes revenge by visiting—and biting— Mina at least three times. Dracula also feeds Mina his blood, creating a spiritual bond between them to control her. The only way to forestall this is to kill Dracula first. Mina slowly succumbs to the blood of the vampire that flows through her veins, switching back and forth from a state of consciousness to a state of semi-trance during which she is telepathically connected with Dracula. Can they save Mina in time or will Dracula claim another victim?