I was housebound and often bedridden for 15 years with severe Chronic Fatigue Syndrome. I tried many treatment approaches but nothing had any beneficial effect. I began working with Dr. Goldstein in 2001, following the experimental drug protocol set forth in this book. I was on the meds he prescribed for 3 years. During that time, I gradually recovered. I am now off the meds, working fulltime, and living a normal life. I know this approach does not work for everyone, but it has worked for many people with CFS, and I would recommend giving it serious consideration. Dr. Goldstein's hypothesis is that CFS is the result of a malfunction of the nervous system in which the neurons are over-responsive to stimuli. Sounds, smells, bright lights, stress, etc. all over-stimulate the over-reactive nervous system, causing fatigue and adrenal exhaustion. This is certainly consistent with my own experience of the illness. The meds reduce synaptic transmission. Over time, they can restore the nervous system to normal functioning.