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Coronavirus Replication and Reverse Genetics (Current Topics in Microbiology and Immunology) (2004) (edit title/settings)

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Until late 1960s the coronaviruses were not recognized as pathogens responsible for human diseases (common cold), and it has been in 2003 when human coronaviruses (HCoVs) recalled worldwide attention with the emergence of the severe and acute respiratory syndrome (SARS), produced by a... read more

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First Sentence edit see section history

Despite its unique property as the largest of the known plus-strand RNA genomes, the coronavirus genome shares with those of other plus-strand RNA viruses (excepting retroviruses) the properties of (1) infectiousness <and not using a packaged RNA-dependent RNA polymerase (RdRp)> (Brian et al. 1980; Schochetman et al. 1977) and (2) replication in the cytoplasm in close association with cellular membranes (Denison et al. 1999; Dennis and Brian 1982; Gosert et al. 2002; Sethna and Brian 1997; Shi et al. 1999; van der Meer et al. 1999).

First Edition edit see section history

Original Language: English
Publisher: Springer-Verlag
Country: Add the country of publication.
Publication Date: 2004
ISBN: 3540214941
Page Count: 257

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