Early childhood details can be drawn from Annie Dillard's autobiography, An American Childhood (1987), about growing up in the Point Breeze neighborhood of Pittsburgh. It starts in 1950 when she was five. Like Russell Baker's Growing Up, Dillard's memoir An American Childhood focuses on her parents and some of her intellectual enthusiasms rather than on herself. She grew up in Pittsburgh in the fifties in "a house full of comedians." She describes her mother as an energetic non-conformist. Her father taught her many useful subjects such as plumbing, economics, and the intricacies of the novel On The Road. She describes in An American Childhood reading a wide variety of subjects including: geology, natural history, entomology, epidemiology, and poetry, among others. Influential books from her youth were: The Natural Way to Draw and Field Book of Ponds and Streams. Her days were filled with exploring, piano and dance classes, rock and bug collecting, drawing, and reading books from the public library including natural history and military history, such as World War II.
As a child, Dillard attended the Shadyside Presbyterian Church in Pittsburgh, though her parents did not attend. She spent four summers at the First Presbyterian Church (FPC) Camp in Ligonier, Pennsylvania. As an adolescent she quit attending church because of "hypocrisy." When she told her minister of her decision, he gave her a stack of books by C. S. Lewis, and that resolved her rebellion.
She attended Pittsburgh Public Schools until fifth grade, and The Ellis School from then until college.